Robin hussmann biography
Published in final edited form as: Cell Metab. 2022 Nov 1;34(11):1620–1653. doi: 10.1016/j.cmet.2022.10.008
SUMMARY
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue that mitochondria are the processor of the cell, and together with the nucleus and other organelles they constitute the mitochondrial information processing system (MIPS). In a three-step process, mitochondria (1) sense and respond to both endogenous and environmental inputs through morphological and functional remodeling; (2) integrate information through dynamic, network-based physical interactions and diffusion mechanisms; and (3) produce output signals that tune the functions of other organelles and systemically regulate physiology. This input-to-output transformation allows mitochondria to transduce metabolic, biochemical, neuroendocrine, and other local or systemic signals that enhance organismal adaptation. An explicit focus on mitochondrial signal transduction emphasizes the role of communication in mitochondrial biology. This framework also opens new avenues to understand how mitochondria mediate inter-organ processes underlying human health.
INTRODUCTION
Our collective view of mitochondria evolved from that of dynamic cytoplasmic granules or “bioblasts” to bean-shaped ATP-synthesizing chemiosmotic machines, motivating the popular “powerhouse of the cell” analogy. Subsequently, mitochondria became known as maternally inherited organelles with their own genome, in which mutations can cause disease, setting off the field of mitochondrial medicine. The imaging of living mitochondria dynamically exchanging proteins and DNA and triggering death via propagating apoptotic waves later sparked an era of mitochondria as dynamic organelles u FAMILY OF ALUMNI & FRIENDS OF THE SCHOOL Gertrude Mary Manning Burns, mother of James J. Burns '03 (Mary Fran Palmisano '00), Patrick Burns '05 (expected), Maureen E. Burns Hallman '06, and Carolyn A. Burns '07; sister of the late Patrick J. Manning '62; aunt of Marisa A. Martinez '91, Suzanne M. Martinez '93, Alex P. Martinez '97, Margo Martinez Marasa '98. Marianne Cantafio, wife of Frank J. Cantafio '60; sister-in-law of William Cantafio '80. Charles Cernock (November 2022) Barbara Ann Farrell, grandmother of Caroline Farrell '19, Katlin A. Farrell '21, Lauren E. Farrell '22, Jack D. Perreault '23 and Kevin N. Perreault '25. Kevin R. Foy, brother-in-law of Thomas E. Brabec '73. Margaret Harmon, wife of the late Donald F. Harmon '46; mother of Senator Don Harmon '84, grandmother of Donald F. Harmon '18, Frances Harmon '21, Daniel Bell '22, and Margaret Harmon '22; sister-in-law of the late James W. Harmon '38, the late Joseph E. Harmon '43, and the late Leo J. Harmon '50; aunt of Gerald R. Harmon '66, Thomas P. Harmon '67, Leo J. Harmon, Jr. '80, and Peter J. Harmon '81. Hon. James F. Henry, father of Nicholas R. Henry '10. Blake Hounshell, husband of Sandy Y. Choi '95. Durele K. Koster, mother of Andrew C. Koster '87. Patricia Macie, wife of Joseph C. Macie '66. Theophilus Moore, Jr., father of Torrence Moore '88. Jeanne Petruzzelli, wife of Vito G. Petruzzelli '51; mother of Guy J. Petruzzelli '77, M.D. Ph.D.; aunt of Guy M. Petruzzelli, Jr. '91, Laura Petruzzelli Fairclough '93, Dominic A. Petruzzelli '95; sister of the late Roger A. DeVito '54. Joseph F. Repetto, grandfather of Francis Viero '22. Mary Catherine Crowley Ryan, mother of Allan "Kelly" Ryan '91 (Dr. Anne Daley Ryan '93), Brian Ryan and Catherine "C.C." Rya “Book Robin. Book him now. Not only does he have the most compelling and important content that the world needs to know about, but he takes you on an adventure with him right from your seat. He knows how to play off the audience and his confidence is organic and contagious. He is wonderful to work with—organized, dedicated and so much fun. I work with many speakers and by far, he was one of the best decisions we ever made. If you’re looking for a speaker who gets conversations going beyond event day, look no further. He is authentic as authentic comes.” —Jess Teutonico, Executive Director, We Are Family Foundation and Curator, TEDxTeen “Robin was a refreshing change from our “normal” external speakers. He fully connected and engaged the younger generation in particular (our audience were mostly in their 20s). By combining the environment with adventuring, it gives a more interesting angle to pure “environment” talks, which risk a boring preach leaving you feeling guilty and overwhelmed. Many in the audience observed that they subsequently talked to friends about the issues, and had animated conversations with those present on the night. These are the current issues facing our world today and Robin tackles them with the right level of seriousness, but mostly with humor and fun stories.” —Quote from a Partner at a Big 4 Professional Services firm “On behalf of the local staff association Green Team, we invited Robin to visit our UNICEF New York office in May 2017. We hoped Robin would help us trigger some reflection by UNICEF colleagues and inspire them to adopt more sustainable habits, like creating less trash. Robin generously agreed. He wore his trash suit to welcome our staff in the morning and talked to them about individual waste and how to reduce their personal footprints. Robin’s presence was incredibly inspiring for our staff and his example a great .In Memoriam
Speaking Testimonials for Robin Greenfield