Louis koo tin lok biography of abraham

Published in final edited form as: Sci Transl Med. Apr 6;3(77)sr1. doi: /scitranslmed

Abstract

Alzheimer’s disease (AD) was first described little more than years ago. It is the most common cause of dementia with an estimated prevalence of 30 million people worldwide, a number that is expected to quadruple in 40 years. There currently is no effective treatment that delays the onset or slows the progression of AD. However, major scientific advances in the areas of genetics, biochemistry, cell biology, and neuroscience over the last 25 years have changed the way we think about AD and offer hope that, if the disease is detected prior to the onset of overt symptoms and signs, it is possible that treatments based on knowledge of underlying pathogenesis can and will be effective.

Overview

Alois Alzheimer, a German psychiatrist, reported at a meeting in Tübingen, Germany, in his clinicopathological study of a woman who presented with a “peculiar” dementia at age 51 years. Alzheimer correlated the woman’s cognitive and behavioral features with histopathological findings of “miliary foci” and neurofibrillary change in the cerebral cortex following her death at 55 years (1). In the years since Alzheimer’s original case report and particularly in the past 3 decades, much has been learned about Alzheimer’s disease (AD). In this review, we will describe the clinical and pathological features of AD and highlight its importance as a global public health problem of immense proportions, both today and in decades to come. We will also discuss the challenges in translating scientific findings into new treatments to improve cognitive function, slow progression, delay the onset, and prevent AD. Studies of AD molecular pathology provided the findings that guided geneticists in the late s to important initial discoveries. In turn, the basic understanding of AD started with the identification of genetic changes and their associated ce

film

The White Storm 2: Drug Lords is a Hong Kong action film directed by Herman Yau, produced by and starring Andy Lau. The film is a thematic sequel in-title-only to the film The White Storm with a new storyline and stars returning cast member Louis Koo in a different role.

The film was first announced on 15 March Production for The White Storm 2: Drug Lords began on 23 June , and wrapped up on 12 September The film was theatrically released on 5 July , in China, on 12 July , in Taiwan, and on 16 July , in Hong Kong. The film was also selected to be the closing film for 18th New York Asian Film Festival on 14 July It was selected as the Hong Kong entry for the Best International Feature Film at the 92nd Academy Awards, but it was not nominated.

The White Storm 2: Drug Lords was a major commercial success, grossing a total of US$ million worldwide against a budget of US$25 million. The film receiv

Michael A. Bushey Glenn A. Mcconkey Ramesh Aacharya Mette Aadahl Rachel Aaron Eske Aasvang Rusnani Ab Latif Ane Abad Motos Judith Abal Julie Abayomi Ali Abbara Ansar Abbas Qalab Abbas Samira Abbasgholizadeh Rahimi Ibrahim M Abbass Mary Abboah-Offei Amir Abdallah Yaser Abdallah Christina Abdel Shaheed Enas Mahrous Abdelaziz Ibtihal Abdelgadir Ahmad Abdin Senbeta Guteta Abdissa Saad Abdiwali Monireh Abdollahi Rosliza Abdul Manaf Faizul Akmal Abdul Rahim Abdul-Fatawu Abdulai Heshu Abdullah-Koolmees Kawsari Abdullah Jabir Abdullakutty Yousif Abdulraheem Aisha Abdurrahman Mesfin Abebe Parvin Abedi Roberto Ariel Abeldaño Zuñiga Yirgalem Abere Saba Abidi Ajibola Abioye John Abisheganaden Theodore Joseph J. Ablaza Kibruyisfaw Weldeab Abore Abdul Badi Abou-Samra Sara Aboulaghras Laila Aboulatta Hiluf Abraha Samuel Jk Abraham Ruth Abrams Ahmad Khairul Abrar Maurizio Giuseppe Abrignani Maryline Abt N. Abu Rached Arsalan Abu-Much Amani Abu-Shaheen Alaa Abuawad Mohamed Abuelazm Alhassan Abukari Jose Manuel Aburto Aws Khalid Abushanab Tamar Abzhandadze María Acevedo-Nuevo Aishwarya Acharya Kiran Acharya Krishna Acharya Preetam Acharya Shiva Raj Acharya Subhendu Acharya Tom Achoki Carlos Acuña-Villaorduña Yuichi Adachi Balázs Ádám Ishag Adam Rosalind Adam Sumaiya Adam Margaret E. Adamek April Dione Adams Danielle R. Adams Adewole S. Adamson Andrew Adamu Jordi Adamuz Philip B Adebayo Adegboyega Adebola Muhammad Adeel Oluseyi Adejumo Olajide A Adekunle Ramu Adela Nicolas Adenis Halimat Adedeji Adenola Babafunso A. Mahiuddin Ahammed Susannah Ahern Mia Ahlberg Sharique Ahmad Aryati Ahmad Ayesha Ahmad Danish Ahmad Huda Ahmad Shoaib Ahmad Hasan N. Ahmadabad Fazlollah Ahmadi Mehdi Ahmadinejad Habibeh Ahmadipour Yahya Ahmadipour Khadijeh Ahmadzadeh Wesam S Ahmed Amr Ahmed El-Arabey Bawan Ahmed Hamdia Ahmed Montasir Ahmed Raheel Ahmed Sirwan Khalid Ahmed Tanvir Ahmed Eunkyoung Ahn Ludwig Serge Aho Katherine Ahrens Marilyn Ahun Jun Ai Josephine Aikpitanyi Nagh